Keratoconjunctivitis sicca, more commonly known as dry eye, is an extremely common and often unrecognized disease. It is the condition in ophthalmology that in its mild grade of severity will affect most of the population at one time or other.
Due to a wide variety of presentations and symptoms, it often frustrates the ophthalmologists as well as patients.
Due to multifactorial and elusive etiology, it is often challenging to treat dry eye. Ocular surface disorders are also clinically important to treat especially in terms of visual acuity. Xero-dacryology is therefore becoming a very important branch of ophthalmology. Recent studies have given insight into the inflammatory etiology of dry eye. The conventional and main approach to the treatment of dry eye is providing lubricating eye drops or tear substitutes.
However, the newer treatment approach is to target the underlying cause of dry eye instead of conventional symptomatic relief.
In light of the above knowledge, the present article focuses on newer theories on pathogenesis of dry eye and their impact on dry eye management.
There has been considerable increase in knowledge regarding pathogenesis of dry eye. Though the term keratoconjunctivitis sicca (KCS) was used for more than 50 years, it is only recently recognized that inflammation of the ocular surface is part of the pathophysiology of dry eye. In KCS patients, ocular surface inflammation can be evaluated as both the cause and the consequence of cell damage. A dangerous vicious cycle ensures between ocular inflammation and dry eye, which in turn may lead to sight-threatening complications. The role of inflammatory cytokines and matrix metalloproteinases (MMPs) in the pathogenesis of dry eye seems to be very important for both the easier understanding of KCS and for the discovery of new therapeutic agents.
|Eye Care Services||Cataract , Eye Examination|
|Eye Diseases||Dry Eye Syndrome|
|Journal Topics||Diseases Diagnoses|
|Journal Types||Images Included, Information, Videos- Training|
|Medical Professionals||Eye Care Professionals (ECP)|
|Source Verified: Health News Organizations||NEI (National Eye Institute)|
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